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COC use increases the hydroxylation, methylation, and conjugation of estrone Other studies 7,8,9 have shown that the use of synthetic hormones reduces circulatory progesterone and E2 levels

[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Nunez-Castilla J., Stebliankin V., Baral P., Balbin C.A., Sobhan M., Cickovski T., Mondal A.M., Narasimhan G., Chapagain P., Mathee K., et al

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Sun H, Brocato J, Costa M (2015) Oral chromium exposure and toxicity